FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
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ABSTRACT:
SUBMITTER: Kim BK
PROVIDER: S-EPMC4578624 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
Kim Bong-Kyu BK Yoo Hye-In HI Kim Injung I Park Jongkeun J Kim Yoon Sungjoo S
BMB reports 20150601 6
Colorectal cancer (CRC), the third most common cancer worldwide, also has the highest rate of cancer-related morbidity and mortality. WNT signaling is initiated by binding of WNT to various receptors, including frizzleds (FZDs), and plays a critical role in CRC and other tumor development by regulating proliferation, differentiation, migration, apoptosis, and polarity. Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in s ...[more]
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