Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NF?B2/p100.
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ABSTRACT:
SUBMITTER: Toledano V
PROVIDER: S-EPMC4579314 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100.
Toledano Víctor V Hernández-Jiménez Enrique E Cubillos-Zapata Carolina C Flandez Marta M Álvarez Enrique E Varela-Serrano Aníbal A Cantero Ramón R Valles Gema G García-Rio Francisco F López-Collazo Eduardo E
Mediators of inflammation 20150909
We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in ...[more]
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