Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4579647 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Zhang Lei L Pan Zhiming Z Kang Xilong X Yang Yun Y Kang Heekap H Zhang Na N Rosati James M JM Jiao Xinan X
Cellular & molecular immunology 20140908 5
Toll-like receptor 5 (TLR5) signaling in response to flagellin is dispensable for inducing humoral immunity, but alterations of aa 89-96, the TLR5 binding site, significantly reduced the adjuvanticity of flagellin. These observations indicate that the underlying mechanism remains incompletely understood. Here, we found that the native form of Salmonella typhimurium aa 89-96-mutant flagellin extracted from flagella retains some TLR5 recognition activity, indicating that aa 89-96 is the primary, b ...[more]