Ontology highlight
ABSTRACT:
SUBMITTER: Chaumet A
PROVIDER: S-EPMC4579783 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chaumet Alexandre A Wright Graham D GD Seet Sze Hwee SH Tham Keit Min KM Gounko Natalia V NV Bard Frederic F
Nature communications 20150910
Endocytosis directs molecular cargo along three main routes: recycling to the cell surface, transport to the Golgi apparatus or degradation in endolysosomes. Pseudomonas exotoxin A (PE) is a bacterial protein that typically traffics to the Golgi and then the endoplasmic reticulum before translocating to the cytosol. Here we show that a substantial fraction of internalized PE is also located in nuclear envelope-associated endosomes (NAE), which display limited mobility, exhibit a propensity to un ...[more]