Outcomes with prolonged clopidogrel therapy after coronary stenting in patients with chronic kidney disease.

ABSTRACT:

Objectives

Patients with chronic kidney disease (CKD) are at high risk of death or myocardial infarction (MI) after percutaneous coronary interventions (PCI). We assessed whether prolonged dual antiplatelet therapy beyond the recommended 12 months may prevent adverse outcomes in patients with CKD receiving drug-eluting stents (DES) or bare-metal stents (BMS).

Methods

We studied all Veterans receiving PCI with BMS or first-generation DES in the Veterans Affairs (VA) Healthcare System between 2002 and 2006, classified by CKD (estimated glomerular filtration rate <60 mL/min) or normal renal function. We used landmark analyses from 12 months after PCI with Cox proportional hazards multivariable and propensity-adjusted models to assess the effect of prolonged clopidogrel (more th

SUBMITTER: Siddiqi OK 

PROVIDER: S-EPMC4580134 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature