Unknown

Dataset Information

0

Correlates of Adherence to Varenicline Among HIV+ Smokers.


ABSTRACT: Low rates of adherence to smoking cessation pharmacotherapy may limit the effectiveness of treatment. However, few studies have examined adherence in smoking cessation trials thus, there is a limited understanding of factors that influence adherence behaviors. This brief report analyzes correlates of adherence to varenicline among people living with HIV/AIDS.Study participants were recruited from three HIV care centers in New York City and enrolled in a three-arm randomized controlled pilot study in which all subjects received varenicline. At the 1-month study visit, there were no significant differences in adherence by study condition, therefore we combined treatment arms to examine correlates of adherence (n = 127). We used pill counts to assess varenicline adherence, defined as taking at least 80% of the prescribed dose. We conducted a multivariate path analysis to assess factors proposed by the information-motivation-behavioral skills model to predict adherence.Only 56% of smokers were at least 80% adherent to varenicline at 1 month. Adherence-related information, self-efficacy, a college degree, and non-Hispanic white race/ethnicity were associated with increased varenicline adherence. In path analysis, information and motivation were associated with increased adherence self-efficacy, and adherence self-efficacy was associated with increased adherence, but with marginal significance. These associations with adherence were no longer significant after controlling for race/ethnicity and education.Further exploration of the role of a modifiable correlates of adherence, such as adherence-related information, motivation and self-efficacy is warranted. Interventions are needed that can address disparities in these and other psychosocial factors that may mediate poor medication adherence.

SUBMITTER: Shelley D 

PROVIDER: S-EPMC4580547 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Correlates of Adherence to Varenicline Among HIV+ Smokers.

Shelley Donna D   Tseng Tuo-Yen TY   Gonzalez Mirelis M   Krebs Paul P   Wong Selena S   Furberg Robert R   Sherman Scott S   Schoenthaler Antoinette A   Urbina Anthony A   Cleland Charles M CM  

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20150801 8


<h4>Introduction</h4>Low rates of adherence to smoking cessation pharmacotherapy may limit the effectiveness of treatment. However, few studies have examined adherence in smoking cessation trials thus, there is a limited understanding of factors that influence adherence behaviors. This brief report analyzes correlates of adherence to varenicline among people living with HIV/AIDS.<h4>Methods</h4>Study participants were recruited from three HIV care centers in New York City and enrolled in a three  ...[more]

Similar Datasets

| S-EPMC7572610 | biostudies-literature
| S-EPMC7125016 | biostudies-literature
| S-EPMC5554578 | biostudies-literature
| S-EPMC3432278 | biostudies-other
| S-EPMC6588414 | biostudies-literature
| S-EPMC3438402 | biostudies-literature
| S-EPMC5217903 | biostudies-literature
| S-EPMC4151018 | biostudies-literature
| S-EPMC2793070 | biostudies-literature
| S-EPMC4839527 | biostudies-literature