Ontology highlight
ABSTRACT:
SUBMITTER: Longchamp A
PROVIDER: S-EPMC4580578 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150923 9
Venous bypass grafts often fail following arterial implantation due to excessive smooth muscle cells (VSMC) proliferation and consequent intimal hyperplasia (IH). Intercellular communication mediated by Connexins (Cx) regulates differentiation, growth and proliferation in various cell types. Microarray analysis of vein grafts in a model of bilateral rabbit jugular vein graft revealed Cx43 as an early upregulated gene. Additional experiments conducted using an ex-vivo human saphenous veins perfus ...[more]