Ontology highlight
ABSTRACT:
SUBMITTER: Noble R
PROVIDER: S-EPMC4581036 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Noble Robert R Kaltz Oliver O Hochberg Michael E ME
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20150701 1673
Peto's paradox is the lack of the expected trend in cancer incidence as a function of body size and lifespan across species. The leading hypothesis to explain this pattern is natural selection for differential cancer prevention in larger, longer lived species. We evaluate whether a similar effect exists within species, specifically humans. We begin by reanalysing a recently published dataset to separate the effects of stem cell number and replication rate, and show that each has an independent e ...[more]