Metassembler: merging and optimizing de novo genome assemblies.
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ABSTRACT:
SUBMITTER: Wences AH
PROVIDER: S-EPMC4581417 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Metassembler: merging and optimizing de novo genome assemblies.
Wences Alejandro Hernandez AH Schatz Michael C MC
Genome biology 20150924
Genome assembly projects typically run multiple algorithms in an attempt to find the single best assembly, although those assemblies often have complementary, if untapped, strengths and weaknesses. We present our metassembler algorithm that merges multiple assemblies of a genome into a single superior sequence. We apply it to the four genomes from the Assemblathon competitions and show it consistently and substantially improves the contiguity and quality of each assembly. We also develop guideli ...[more]
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Project description: Not available
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