Covariance-based analyses of biological pathways.
Ontology highlight
ABSTRACT:
SUBMITTER: Danaher P
PROVIDER: S-EPMC4581526 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Covariance-based analyses of biological pathways.
Biometrika 20150901 3
The use of high-throughput data to study the changing behavior of biological pathways has focused mainly on examining the changes in the means of pathway genes. In this paper, we propose instead to test for changes in the co-regulated and unregulated variability of pathway genes. We assume that the eigenvalues of previously defined pathways capture biologically relevant quantities, and we develop a test for biologically meaningful changes in the eigenvalues between classes. This test reflects im ...[more]
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