Ontology highlight
ABSTRACT:
SUBMITTER: Cheng L
PROVIDER: S-EPMC4581877 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Cheng Lina L Zhang Jiayin J Ahmad Sana S Rozier Lorene L Yu Haiqian H Deng Haiteng H Mao Yinghui Y
Developmental cell 20110301 3
Proper bipolar attachment of sister kinetochores to the mitotic spindle is critical for accurate chromosome segregation in mitosis. Here we show an essential role of the formin mDia3 in achieving metaphase chromosome alignment. This function is independent of mDia3 actin nucleation activity, but is attributable to EB1-binding by mDia3. Furthermore, the microtubule binding FH2 domain of mDia3 is phosphorylated by Aurora B kinase in vitro, and cells expressing the nonphosphorylatable mDia3 mutant ...[more]