Ontology highlight
ABSTRACT:
SUBMITTER: Wunderlich Z
PROVIDER: S-EPMC4581983 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Wunderlich Zeba Z Bragdon Meghan D J MD Vincent Ben J BJ White Jonathan A JA Estrada Javier J Estrada Javier J DePace Angela H AH
Cell reports 20150903 11
Many developmental genes are controlled by shadow enhancers—pairs of enhancers that drive overlapping expression patterns. We hypothesized that compensatory evolution can maintain the total expression of a gene, while individual shadow enhancers diverge between species. To test this hypothesis, we analyzed expression driven by orthologous pairs of shadow enhancers from Drosophila melanogaster, Drosophila yakuba, and Drosophila pseudoobscura that control expression of Krüppel, a transcription fac ...[more]