Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.
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ABSTRACT:
SUBMITTER: McKinnon DD
PROVIDER: S-EPMC4582033 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.
McKinnon Daniel D DD Domaille Dylan W DW Domaille Dylan W DW Cha Jennifer N JN Anseth Kristi S KS
Advanced materials (Deerfield Beach, Fla.) 20131011 6
Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts. ...[more]
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