Robust Optimization of Biological Protocols.
Ontology highlight
ABSTRACT:
SUBMITTER: Flaherty P
PROVIDER: S-EPMC4582800 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Robust Optimization of Biological Protocols.
Flaherty Patrick P Davis Ronald W RW
Technometrics : a journal of statistics for the physical, chemical, and engineering sciences 20150713 2
When conducting high-throughput biological experiments, it is often necessary to develop a protocol that is both inexpensive and robust. Standard approaches are either not cost-effective or arrive at an optimized protocol that is sensitive to experimental variations. We show here a novel approach that directly minimizes the cost of the protocol while ensuring the protocol is robust to experimental variation. Our approach uses a risk-averse conditional value-at-risk criterion in a robust paramete ...[more]
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