Ontology highlight
ABSTRACT:
SUBMITTER: Wojcik KA
PROVIDER: S-EPMC4582917 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Wójcik Katarzyna A KA Synowiec Ewelina E Polakowski Piotr P Błasiak Janusz J Szaflik Jerzy J Szaflik Jacek P JP
Medical science monitor : international medical journal of experimental and clinical research 20150921
BACKGROUND Fuchs endothelial corneal dystrophy (FECD) is a corneal disease characterized by abnormalities in the Descemet membrane and the corneal endothelium. The etiology of this disease is poorly understood. An increased level of oxidative DNA damage reported in FECD corneas suggests a role of DNA base excision repair (BER) genes in its pathogenesis. In this work, we searched for the association between variation of the PARP-1, NEIL1, POLG, and XRCC1 genes and FECD occurrence. MATERIAL AND ME ...[more]