Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
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ABSTRACT:
SUBMITTER: Ayo CM
PROVIDER: S-EPMC4583584 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
Ayo Christiane Maria CM Oliveira Amanda Priscila de AP Camargo Ana Vitória da Silveira AV Mattos Cinara Cássia Brandão de CC Bestetti Reinaldo Bulgarelli RB Mattos Luiz Carlos de LC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20150630 8
MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD. ...[more]
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