Predictive factors for immunotherapy in melanoma.
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ABSTRACT:
SUBMITTER: Teixido C
PROVIDER: S-EPMC4583591 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Predictive factors for immunotherapy in melanoma.
Teixidó Cristina C González-Cao Maria M Karachaliou Niki N Rosell Rafael R
Annals of translational medicine 20150901 15
Immunotherapy has emerged as an exciting strategy for cancer treatment. Therapeutic blockade of immune checkpoint regulators favors the ability of T cell responses to increase anti-tumor immunity. The cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death-1 (PD-1) are two T cell-inhibitory receptors with independent mechanisms of action. Immune checkpoint inhibitors targeting either CTLA-4, PD-1 or its ligand PD-L1 are currently yielding promising results in terms of effi ...[more]
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