Ontology highlight
ABSTRACT:
SUBMITTER: Martinaud C
PROVIDER: S-EPMC4583614 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Martinaud Christophe C Desterke Christophe C Konopacki Johanna J Vannucchi Alessandro M AM Pieri Lisa L Guglielmelli Paola P Dupriez Brigitte B Ianotto Jean-Christophe JC Boutin Laetitia L Lataillade Jean-Jacques JJ Le Bousse-Kerdilès Marie-Caroline MC
Genomics data 20150429
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm whose severity and treatment complexity are attributed to the presence of bone marrow (BM) fibrosis and alterations of stroma impairing the production of normal blood cells. Despite the recently discovered mutations including the JAK2V617F mutation in about half of patients, the primitive event responsible for the clonal proliferation is still unknown. In the highly inflammatory context of PMF, the presence of fibrosis associate ...[more]