Gene expression profile in the fat tissue of Fsp27 deficient mice.
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ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC4583699 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Gene expression profile in the fat tissue of Fsp27 deficient mice.
Xu Li L Xia Xiayu X Arshad Muhammad M Zhou Linkang L
Genomics data 20150711
Fsp27 is a lipid droplet-associated protein almost exclusively expressed in adipocytes where it facilitates unilocular lipid droplet formation. In mice, Fsp27 deficiency is associated with increased basal lipolysis, browning of white fat and a healthy metabolic profile, whereas energetically challenged Fsp27 deficient mice (ob/ob/Fsp27 (-/-)) show dramatically reduced fat mass, hepatic steatosis and insulin resistance which represents a typical lipodystrophy phenotype. Here, we investigate the e ...[more]
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