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Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning.

ABSTRACT: Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. Moreover, learning with this form of plasticity leaves a hidden postsynaptic memory trace that enables fast relearning of previously stored information, providing a cellular substrate for memory savings. Our results reveal essential roles for presynaptic plasticity that are missed when only postsynaptic expression of long-term plasticity is considered, and suggest an experience-dependent distribution of pre- and postsynaptic strength changes.

SUBMITTER: Costa RP

PROVIDER: S-EPMC4584257 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning.

Costa Rui Ponte RP Froemke Robert C RC Sjöström P Jesper PJ van Rossum Mark Cw MC

eLife 20150826

Although it is well known that long-term synaptic plasticity can be expressed both pre- and postsynaptically, the functional consequences of this arrangement have remained elusive. We show that spike-timing-dependent plasticity with both pre- and postsynaptic expression develops receptive fields with reduced variability and improved discriminability compared to postsynaptic plasticity alone. These long-term modifications in receptive field statistics match recent sensory perception experiments. ...[more]

PMID: 26308579

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