Genotype-Epigenotype Interaction at the IGF2 DMR.
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ABSTRACT:
SUBMITTER: Murphy SK
PROVIDER: S-EPMC4584329 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Genotype-Epigenotype Interaction at the IGF2 DMR.
Murphy Susan K SK Erginer Erin E Huang Zhiqing Z Visco Zachary Z Hoyo Cathrine C
Genes 20150828 3
Paternally expressed Insulin-like Growth Factor II (IGF2) encodes a gene whose protein product functions as a potent growth mitogen. Overexpression of IGF2 has been implicated in a wide number of disorders and diseases. IGF2 is regulated in part by differential methylation of the two parentally derived alleles. The differentially methylated region (DMR) located upstream of the imprinted promoters of IGF2 exhibits plasticity under environmental stress and is hypomethylated in several types of can ...[more]
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