Ontology highlight
ABSTRACT:
SUBMITTER: Simons CC
PROVIDER: S-EPMC4585376 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Simons Colinda C J M CC Schouten Leo J LJ Godschalk Roger W L RW van Engeland Manon M van den Brandt Piet A PA van Schooten Frederik J FJ Weijenberg Matty P MP
Scientific reports 20150918
Interrelationships between insulin-like growth factors (IGFs), hyperinsulinaemia, diabetes, and colorectal cancer (CRC) indicate involvement of IGFs in colorectal tumorigenesis. We investigated the CRC risk associated with 24 single nucleotide polymorphisms (SNPs) in 9 genes related to the IGF pathway and an IGF1 19-CA repeat polymorphism. Variants were selected from literature and genotyped in toenail DNA from 3,768 subcohort members and 2,580 CRC cases from the Netherlands Cohort Study, which ...[more]