Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment.
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ABSTRACT:
SUBMITTER: Kimmel RA
PROVIDER: S-EPMC4585597 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment.
Kimmel Robin A RA Dobler Stefan S Schmitner Nicole N Walsen Tanja T Freudenblum Julia J Meyer Dirk D
Scientific reports 20150918
Diabetes mellitus is characterized by disrupted glucose homeostasis due to loss or dysfunction of insulin-producing beta cells. In this work, we characterize pancreatic islet development and function in zebrafish mutant for pdx1, a gene which in humans is linked to genetic forms of diabetes and is associated with increased susceptibility to Type 2 diabetes. Pdx1 mutant zebrafish have the key diabetic features of reduced beta cells, decreased insulin and elevated glucose. The hyperglycemia respon ...[more]
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