Ontology highlight
ABSTRACT:
SUBMITTER: Chai X
PROVIDER: S-EPMC4585731 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Chai Xinqun X Chu Hongpeng H Yang Xuan X Meng Yuanpu Y Shi Pengfei P Gou Shanmiao S
Scientific reports 20150922
The prognosis of pancreatic cancer remains dismal, with little advance in chemotherapy because of its high frequency of chemoresistance. Metformin is widely used to treat type II diabetes, and was shown recently to inhibit pancreatic cancer stem cell proliferation. In the present study, we investigated the role of metformin in chemoresistance of pancreatic cancer cells to gemcitabine, and its possible cellular and molecular mechanisms. Metformin increases sensitivity of pancreatic cancer cells t ...[more]