Ontology highlight
ABSTRACT:
SUBMITTER: Gabarrini G
PROVIDER: S-EPMC4585897 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gabarrini Giorgio G de Smit Menke M Westra Johanna J Brouwer Elisabeth E Vissink Arjan A Zhou Kai K Rossen John W A JW Stobernack Tim T van Dijl Jan Maarten JM van Winkelhoff Arie Jan AJ
Scientific reports 20150925
Periodontitis is an infective process that ultimately leads to destruction of the soft and hard tissues that support the teeth (the periodontium). Periodontitis has been proposed as a candidate risk factor for development of the autoimmune disease rheumatoid arthritis (RA). Porphyromonas gingivalis, a major periodontal pathogen, is the only known prokaryote expressing a peptidyl arginine deiminase (PAD) enzyme necessary for protein citrullination. Antibodies to citrullinated proteins (anti-citru ...[more]