Ontology highlight
ABSTRACT:
SUBMITTER: Alves MM
PROVIDER: S-EPMC4585940 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Scientific reports 20150928
Tuberous sclerosis complex (TSC) is caused by inactivating mutations in either TSC1 or TSC2 and is characterized by uncontrolled mTORC1 activation. Drugs that reduce mTOR activity are only partially successful in the treatment of TSC, suggesting that mTOR-independent pathways play a role in disease development. Here, kinome profiles of wild-type and Tsc2(-/-) mouse embryonic fibroblasts (MEFs) were generated, revealing a prominent role for PAK2 in signal transduction downstream of TSC1/2. Furthe ...[more]