Ontology highlight
ABSTRACT:
SUBMITTER: Guo J
PROVIDER: S-EPMC4586487 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Guo Jihua J Jia Jun J Jia Rong R
Scientific reports 20150929
Splicing factors are key players in the regulation of alternative splicing of pre-mRNAs. Overexpression of splicing factors, including SRSF3, has been strongly linked with oncogenesis. However, the mechanisms behind their overexpression remain largely unclear. Autoregulation is a common mechanism to maintain relative stable expression levels of splicing factors in cells. SRSF3 regulates its own expression by enhancing the inclusion of an alternative exon 4 with an in-frame stop codon. We found t ...[more]