Ontology highlight
ABSTRACT:
SUBMITTER: Schmandt N
PROVIDER: S-EPMC4586589 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Schmandt Nicolaus N Velisetty Phanindra P Chalamalasetti Sreevatsa V SV Stein Richard A RA Bonner Ross R Talley Lauren L Parker Mark D MD Mchaourab Hassane S HS Yee Vivien C VC Lodowski David T DT Chakrapani Sudha S
The Journal of general physiology 20151001 4
Recent high resolution structures of several pentameric ligand-gated ion channels have provided unprecedented details of their molecular architecture. However, the conformational dynamics and structural rearrangements that underlie gating and allosteric modulation remain poorly understood. We used a combination of electrophysiology, double electron-electron resonance (DEER) spectroscopy, and x-ray crystallography to investigate activation mechanisms in a novel functional chimera with the extrace ...[more]