Ontology highlight
ABSTRACT:
SUBMITTER: Gang H
PROVIDER: S-EPMC4586742 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Gang Hongying H Dhingra Rimpy R Lin Junjun J Hai Yan Y Aviv Yaron Y Margulets Victoria V Hamedani Mohammad M Thanasupawat Thatchawan T Leygue Etienne E Klonisch Thomas T Davie James R JR Kirshenbaum Lorrie A LA
The Journal of cell biology 20150901 7
Herein we describe a novel survival pathway that operationally links alternative pre-mRNA splicing of the hypoxia-inducible death protein Bcl-2 19-kD interacting protein 3 (Bnip3) to the unique glycolytic phenotype in cancer cells. While a full-length Bnip3 protein (Bnip3FL) encoded by exons 1-6 was expressed as an isoform in normal cells and promoted cell death, a truncated spliced variant of Bnip3 mRNA deleted for exon 3 (Bnip3Δex3) was preferentially expressed in several human adenocarcinomas ...[more]