Ontology highlight
ABSTRACT:
SUBMITTER: Tan RJ
PROVIDER: S-EPMC4587687 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Tan Roderick J RJ Zhou Dong D Xiao Liangxiang L Zhou Lili L Li Yingjian Y Bastacky Sheldon I SI Oury Tim D TD Liu Youhua Y
Journal of the American Society of Nephrology : JASN 20150202 10
Extracellular superoxide dismutase (EC-SOD), also known as SOD3, is an antioxidant expressed at high levels in normal adult kidneys. Because oxidative stress contributes to a variety of kidney injuries, we hypothesized that EC-SOD may be protective in CKD progression. To study this hypothesis, we used a murine model of ADR nephropathy characterized by albuminuria and renal dysfunction. We found that levels of EC-SOD diminished throughout the course of disease progression and were associated with ...[more]