Ontology highlight
ABSTRACT:
SUBMITTER: Buchbinder E
PROVIDER: S-EPMC4588295 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Buchbinder Elizabeth E Hodi F Stephen FS
The Journal of clinical investigation 20150901 9
The relationship between cancer and the immune system is complex and provides unique therapeutic opportunities. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory signals. Fully human monoclonal antibodies targeting CTLA-4 have been shown to increase T cell function and antitumor responses in patients with advanced metastatic melanoma. Responses observed with such immune checkpoint therapy can ...[more]