Ontology highlight
ABSTRACT:
SUBMITTER: Liao X
PROVIDER: S-EPMC4588311 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Liao Xudong X Zhang Rongli R Lu Yuan Y Prosdocimo Domenick A DA Sangwung Panjamaporn P Zhang Lilei L Zhou Guangjin G Anand Puneet P Lai Ling L Leone Teresa C TC Fujioka Hisashi H Ye Fang F Rosca Mariana G MG Hoppel Charles L CL Schulze P Christian PC Abel E Dale ED Stamler Jonathan S JS Kelly Daniel P DP Jain Mukesh K MK
The Journal of clinical investigation 20150804 9
Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have shown that the transcription factor Kruppel-like factor 4 (KLF4) governs mitochondrial biogenesis, metabolic function, dynamics, and autophagic clearance. Adult mice with cardiac-specific Klf4 deficiency developed cardiac dysfunction with aging or in response to pressure overload that was characterized by reduced myocardial ATP levels, el ...[more]