Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
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ABSTRACT:
SUBMITTER: Soylu-Kucharz R
PROVIDER: S-EPMC4588570 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.
Soylu-Kucharz Rana R Adlesic Natalie N Baldo Barbara B Kirik Deniz D Petersén Åsa Å
Scientific reports 20150930
Expression of mutant huntingtin (htt) protein has been shown to cause metabolic imbalance in animal models of Huntington disease (HD). The pathways involved are not fully understood but dysfunction of both the hypothalamus and brown adipose tissue (BAT) has been implicated. Here we show that targeted expression of mutant HTT in the hypothalamus leads to loss of the A13 dopaminergic cell group located in the zona incerta and reduced mRNA expression of neuropeptide Y1 receptor in the hypothalamus. ...[more]
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