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Variation in the ribosome interacting loop of the Sec61? from Giardia lamblia.

ABSTRACT: The interaction between the ribosome and the endoplasmic reticulum-located Sec61 protein translocon is mediated through an arginine residue of Sec61?, which is conserved in all prokaryotic and eukaryotic orthologues characterized to date. Using in silico approaches we report that instead of arginine, this ribosome-interaction function is most likely discharged by a lysine residue in the protist Giardia lamblia. This functional substitution of the R with a K in GlSec61? may have taken place to accommodate a G-rich rRNA.

SUBMITTER: Sinha A

PROVIDER: S-EPMC4588681 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia.

Sinha Abhishek A Ray Atrayee A Ganguly Sandipan S Ghosh Dastidar Shubhra S Sarkar Srimonti S

Biology direct 20150930

The interaction between the ribosome and the endoplasmic reticulum-located Sec61 protein translocon is mediated through an arginine residue of Sec61α, which is conserved in all prokaryotic and eukaryotic orthologues characterized to date. Using in silico approaches we report that instead of arginine, this ribosome-interaction function is most likely discharged by a lysine residue in the protist Giardia lamblia. This functional substitution of the R with a K in GlSec61α may have taken place to ac ...[more]

PMID: 26424409

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