Ontology highlight
ABSTRACT:
SUBMITTER: Bednarek D
PROVIDER: S-EPMC4589159 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Bednarek Dorota D González-Rosa Juan Manuel JM Guzmán-Martínez Gabriela G Gutiérrez-Gutiérrez Óscar Ó Aguado Tania T Sánchez-Ferrer Carlota C Marques Inês João IJ Galardi-Castilla María M de Diego Irene I Gómez Manuel José MJ Cortés Alfonso A Zapata Agustín A Jiménez-Borreguero Luis Jesús LJ Mercader Nadia N Flores Ignacio I
Cell reports 20150828 10
After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate after injury. Complete regeneration of the zebrafish heart is driven by the strong proliferation response of its cardiomyocytes to injury. Here we show that, after cardiac injury in zebrafish, telomerase becomes hyperactivated, and telomeres elongate transiently, preceding a peak of cardiomyocyte proliferation and full organ recovery. Usin ...[more]