Ontology highlight
ABSTRACT:
SUBMITTER: Hayes JE
PROVIDER: S-EPMC4589387 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hayes James E JE Trynka Gosia G Vijai Joseph J Offit Kenneth K Raychaudhuri Soumya S Klein Robert J RJ
PloS one 20150930 9
Though numerous polymorphisms have been associated with risk of developing lymphoma, how these variants function to promote tumorigenesis is poorly understood. Here, we report that lymphoma risk SNPs, especially in the non-Hodgkin's lymphoma subtype chronic lymphocytic leukemia, are significantly enriched for co-localization with epigenetic marks of active gene regulation. These enrichments were seen in a lymphoid-specific manner for numerous ENCODE datasets, including DNase-hypersensitivity as ...[more]