Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4589490 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Zhang Jiangwei J Tripathi Durga Nand DN Jing Ji J Alexander Angela A Kim Jinhee J Powell Reid T RT Dere Ruhee R Tait-Mulder Jacqueline J Lee Ji-Hoon JH Paull Tanya T TT Pandita Raj K RK Charaka Vijaya K VK Pandita Tej K TK Kastan Michael B MB Walker Cheryl Lyn CL
Nature cell biology 20150907 10
Peroxisomes are highly metabolic, autonomously replicating organelles that generate reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells must maintain peroxisome homeostasis, or risk pathologies associated with too few peroxisomes, such as peroxisome biogenesis disorders, or too many peroxisomes, inducing oxidative damage and promoting diseases such as cancer. We report that the PEX5 peroxisome import receptor binds ataxia-telangiectasia mutated (ATM) and ...[more]