Ontology highlight
ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC4590999 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Nature 20070606 7148
A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of tumour suppressor pathways, we compared miRNA expression profiles of wild-type and p53-deficient cells. Here we describe a family of miRNAs, miR-34a-c, whose expression reflected p53 status. Genes encoding miRNAs in the miR-34 family are direct transcriptional targets of p53, whose induction by DNA damage ...[more]