Histone-lysine N-methyltransferase SETDB1 is required for development of the bovine blastocyst.

ABSTRACT: Transcripts derived from select clades of transposable elements are among the first to appear in early mouse and human embryos, indicating transposable elements and the mechanisms that regulate their activity are fundamental to the establishment of the founding mammalian lineages. However, the mechanisms by which these parasitic sequences are involved in directing the developmental program are still poorly characterized. Transposable elements are regulated through epigenetic means, where combinatorial patterns of DNA methylation and histone 3 lysine 9 trimethylation (H3K9me3) suppress their transcription. From studies in rodents, SET domain bifurcated 1 (SETDB1) has emerged as the core methyltransferase responsible for marking transposable elements with H3K9me3 and temporally regulating th

SUBMITTER: Golding MC 

PROVIDER: S-EPMC4591208 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature