Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez PM
PROVIDER: S-EPMC4591215 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Dominguez Pilar M PM Teater Matt M Chambwe Nyasha N Kormaksson Matthias M Redmond David D Ishii Jennifer J Vuong Bao B Chaudhuri Jayanta J Melnick Ari A Vasanthakumar Aparna A Godley Lucy A LA Papavasiliou F Nina FN Elemento Olivier O Shaknovich Rita R
Cell reports 20150910 12
Changes in DNA methylation are required for the formation of germinal centers (GCs), but the mechanisms of such changes are poorly understood. Activation-induced cytidine deaminase (AID) has been recently implicated in DNA demethylation through its deaminase activity coupled with DNA repair. We investigated the epigenetic function of AID in vivo in germinal center B cells (GCBs) isolated from wild-type (WT) and AID-deficient (Aicda(-/-)) mice. We determined that the transit of B cells through th ...[more]