Ontology highlight
ABSTRACT:
SUBMITTER: Wong CO
PROVIDER: S-EPMC4591237 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Wong Ching-On CO Palmieri Michela M Li Jiaxing J Akhmedov Dmitry D Chao Yufang Y Broadhead Geoffrey T GT Zhu Michael X MX Berdeaux Rebecca R Collins Catherine A CA Sardiello Marco M Venkatachalam Kartik K
Cell reports 20150917 12
Here, we evaluate the mechanisms underlying the neurodevelopmental deficits in Drosophila and mouse models of lysosomal storage diseases (LSDs). We find that lysosomes promote the growth of neuromuscular junctions (NMJs) via Rag GTPases and mechanistic target of rapamycin complex 1 (MTORC1). However, rather than employing S6K/4E-BP1, MTORC1 stimulates NMJ growth via JNK, a determinant of axonal growth in Drosophila and mammals. This role of lysosomal function in regulating JNK phosphorylation is ...[more]