Ontology highlight
ABSTRACT:
SUBMITTER: Schulte EC
PROVIDER: S-EPMC4592093 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Schulte Eva C EC Fukumori Akio A Mollenhauer Brit B Hor Hyun H Arzberger Thomas T Perneczky Robert R Kurz Alexander A Diehl-Schmid Janine J Hüll Michael M Lichtner Peter P Eckstein Gertrud G Zimprich Alexander A Haubenberger Dietrich D Pirker Walter W Brücke Thomas T Bereznai Benjamin B Molnar Maria J MJ Lorenzo-Betancor Oswaldo O Pastor Pau P Peters Annette A Gieger Christian C Estivill Xavier X Meitinger Thomas T Kretzschmar Hans A HA Trenkwalder Claudia C Haass Christian C Winkelmann Juliane J
European journal of human genetics : EJHG 20150121 10
Many individuals with Parkinson's disease (PD) develop cognitive deficits, and a phenotypic and molecular overlap between neurodegenerative diseases exists. We investigated the contribution of rare variants in seven genes of known relevance to dementias (β-amyloid precursor protein (APP), PSEN1/2, MAPT (microtubule-associated protein tau), fused in sarcoma (FUS), granulin (GRN) and TAR DNA-binding protein 43 (TDP-43)) to PD and PD plus dementia (PD+D) in a discovery sample of 376 individuals wit ...[more]