The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.
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ABSTRACT:
SUBMITTER: Hwang JC
PROVIDER: S-EPMC4592204 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.
Hwang Jau-Chung JC Sung Wen-Wei WW Tu Hung-Pin HP Hsieh Kun-Chou KC Yeh Chung-Min CM Chen Chih-Jung CJ Tai Hui-Chun HC Hsu Chao-Tien CT Shieh Grace S GS Chang Jan-Gowth JG Yeh Kun-Tu KT Liu Ta-Chih TC
PloS one 20151002 10
Synthetic lethality arises when a combination of mutations in two or more genes leads to cell death. However, the prognostic role of concordant overexpression of synthetic lethality genes in protein level rather than a combination of mutations is not clear. In this study, we explore the prognostic role of combined overexpression of paired genes in lung adenocarcinoma. We used immunohistochemical staining to investigate 24 paired genes in 93 lung adenocarcinoma patients and Kaplan-Meier analysis ...[more]
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