Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC4592361 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Li Changjun C Wang Weishan W Xie Liang L Luo Xianghang X Cao Xu X Wan Mei M
Annals of the New York Academy of Sciences 20150402
Parathyroid hormone (PTH) suppresses the expression of the bone formation inhibitor sclerostin (Sost) in osteocytes by inducing nuclear accumulation of histone deacetylases (HDACs) to inhibit the myocyte enhancer factor 2 (MEF2)-dependent Sost bone enhancer. Previous studies revealed that lipoprotein receptor-related protein 6 (LRP6) mediates the intracellular signaling activation and the anabolic bone effect of PTH. Here, we investigated whether LRP6 mediates the inhibitory effect of PTH on Sos ...[more]