Dataset Information

Multisite evaluations of a T2 -relaxation-under-spin-tagging (TRUST) MRI technique to measure brain oxygenation.

ABSTRACT:

Purpose

Venous oxygenation (Yv ) is an important index of brain physiology and may be indicative of brain diseases. A T2 -relaxation-under-spin-tagging (TRUST) MRI technique was recently developed to measure Yv . A multisite evaluation of this technique would be an important step toward broader availability and potential clinical utilizations of Yv measures.

Methods

TRUST MRI was performed on a total of 250 healthy subjects, 125 from the developer's site and 25 each from five other sites. All sites were equipped with a 3 Tesla (T) MRI of the same vendor. The estimated Yv and the standard error (SE) of the estimation ?Yv were compared across sites.

Results

The averaged Yv and ?Yv across six sites were 61.1%?±?1.4% and 1.3%?±?0.2%, respectively. Multivariate regression analysis showed that the estimated Yv was dependent on age (P?=?0.009) but not on performance site. In contrast, the SE of the Yv estimation was site-dependent (P?=?0.024) but was less than 1.5%. Further analysis revealed that ?Yv was positively associated with the amount of subject motion (P?ConclusionThis work suggests that TRUST MRI can yield equivalent results of Yv estimation across different sites.

SUBMITTER: Liu P

PROVIDER: S-EPMC4592780 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Publications

Multisite evaluations of a T2 -relaxation-under-spin-tagging (TRUST) MRI technique to measure brain oxygenation.

Liu Peiying P Dimitrov Ivan I Andrews Trevor T Crane David E DE Dariotis Jacinda K JK Desmond John J Dumas Julie J Gilbert Guillaume G Kumar Anand A Maclntosh Bradley J BJ Tucholka Alan A Yang Shaolin S Xiao Guanghua G Lu Hanzhang H

Magnetic resonance in medicine 20150404 2

<h4>Purpose</h4>Venous oxygenation (Yv ) is an important index of brain physiology and may be indicative of brain diseases. A T2 -relaxation-under-spin-tagging (TRUST) MRI technique was recently developed to measure Yv . A multisite evaluation of this technique would be an important step toward broader availability and potential clinical utilizations of Yv measures.<h4>Methods</h4>TRUST MRI was performed on a total of 250 healthy subjects, 125 from the developer's site and 25 each from five othe ...[more]

PMID: 25845468

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Project description:OBJECTIVE:To explore whether subregional laminar femorotibial cartilage spin-spin relaxation time (T2) is associated with subsequent radiographic progression and cartilage loss and/or whether one-year change in subregional laminar femorotibial cartilage T2 is associated with concurrent progression in knees with established radiographic OA (ROA). METHODS:In this case-control study, Osteoarthritis Initiative (OAI) knees with medial femorotibial progression were selected based on one-year loss in both quantitative cartilage thickness Magnetic resonance imaging (MRI) and radiographic joint space width (JSW). Non-progressor knees were matched by sex, Body mass index (BMI), baseline Kellgren-Lawrence-grade (2/3), and pain. Baseline and one-year follow-up superficial and deep cartilage T2 was analyzed in 16 femorotibial subregions using multi-echo spin-echo MRI. RESULTS:37 knees showed medial femorotibial progression whereas 37 matched controls had no medial or lateral compartment progression. No statistically significant baseline differences between progressor and non-progressor knees in medial femorotibial cartilage T2 were observed in the superficial (48.9 ± 3.0 ms; 95% CI: [47.9, 49.9] vs 47.8 ± 3.6 ms; 95% CI: [46.6, 49.0], P = 0.07) or deep cartilage layer (40.8 ± 3.6 ms; 95% CI: [39.5, 42.0] vs 40.1 ± 4.7 ms; 95% CI: [38.5, 41.6], P = 0.29). Concurrent T2 change was more pronounced in the deep than the superficial cartilage layer. In the medial femorotibial compartment (MFTC), longitudinal change was greater in the deep layer of progressor than non-progressor knees (1.8 ± 4.5 ms; 95% CI: [0.3, 3.3] vs -0.2 ± 1.9 ms; 95% CI: [-0.8, 0.5], P = 0.02), whereas no difference was observed in the superficial layer. CONCLUSION:Medial compartment cartilage T2 did not appear to be a strong prognostic factor for subsequent structural progression in the same compartment of knees with established ROA, when appropriately controlling for covariates. Yet, deep layer T2 change in the medial compartment occurred concurrent with medial femorotibial progression.

Dataset Information

Multisite evaluations of a T2 -relaxation-under-spin-tagging (TRUST) MRI technique to measure brain oxygenation.

Purpose

Methods

Results

Publications

Multisite evaluations of a T2 -relaxation-under-spin-tagging (TRUST) MRI technique to measure brain oxygenation.

Similar Datasets

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