Ontology highlight
ABSTRACT:
SUBMITTER: Hsu LC
PROVIDER: S-EPMC4593128 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Hsu Lea Chia-Ling LC Nam Sean S Cui Yi Y Chang Ching-Pu CP Wang Chia-Fang CF Kuo Hung-Chih HC Touboul Jonathan D JD Chou Shen-Ju SJ
Proceedings of the National Academy of Sciences of the United States of America 20150914 39
The timing of cortical neurogenesis has a major effect on the size and organization of the mature cortex. The deletion of the LIM-homeodomain transcription factor Lhx2 in cortical progenitors by Nestin-cre leads to a dramatically smaller cortex. Here we report that Lhx2 regulates the cortex size by maintaining the cortical progenitor proliferation and delaying the initiation of neurogenesis. The loss of Lhx2 in cortical progenitors results in precocious radial glia differentiation and a temporal ...[more]