Protocol for a systematic review of the impact of resuscitation fluids on the microcirculation after haemorrhagic shock in animal models.

ABSTRACT:

Background

Modern resuscitation strategies following haemorrhagic shock are influenced by global haemodynamic parameters such as blood pressure and cardiac output. Microcirculatory dysfunction in this context may persist even after restoration of satisfactory global parameters. Additional monitoring of the microcirculatory function may therefore be warranted in order to facilitate goal-directed therapy at a tissue oxygenation level. Although such a phenomenon is recognised in the case of sepsis, clinical evidence regarding the behaviour of the microcirculation following the delivery of resuscitation fluids after haemorrhagic shock is sparse. A summation of the current state of pre-clinical evidence is justified in order to direct avenues for future clinical research.

Methods/des

SUBMITTER: Naumann DN 

PROVIDER: S-EPMC4593218 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature