Ontology highlight
ABSTRACT:
SUBMITTER: Stitzel ML
PROVIDER: S-EPMC4593392 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Stitzel Michael L ML Kycia Ina I Kursawe Romy R Ucar Duygu D
Current diabetes reports 20150901 9
Islets of Langerhans contain multiple hormone-producing endocrine cells controlling glucose homeostasis. Transcription establishes and maintains islet cellular fates and identities. Genetic and environmental disruption of islet transcription triggers cellular dysfunction and disease. Early transcriptional regulation studies of specific islet genes, including insulin (INS) and the transcription factor PDX1, identified the first cis-regulatory DNA sequences and trans-acting factors governing islet ...[more]