Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4593396 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Zhang Huiyuan H Dou Jun J Yu Yang Y Zhao Yanling Y Fan Yihui Y Cheng Jin J Xu Xin X Liu Wei W Guan Shan S Chen Zhenghu Z shi Yan Y Patel Roma R Vasudevan Sanjeev A SA Zage Peter E PE Zhang Hong H Nuchtern Jed G JG Kim Eugene S ES Fu Songbin S Yang Jianhua J
Apoptosis : an international journal on programmed cell death 20150101 1
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibitor INK128 showed inhibitory effects on both anchorage-dependent and independent growth of neuroblastoma cells and significantly enhanced the cytotoxic effects of doxorubicin (Dox) on these cell lines ...[more]