Ontology highlight
ABSTRACT:
SUBMITTER: Saddic LA
PROVIDER: S-EPMC4593826 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Saddic Louis A LA Chang Tzuu-Wang TW Sigurdsson Martin I MI Heydarpour Mahyar M Raby Benjamin A BA Shernan Stanton K SK Aranki Sary F SF Body Simon C SC Muehlschlegel Jochen D JD
Physiological genomics 20150714 10
MicroRNAs (miRNAs) play a significant role in ischemic heart disease. Animal models of left ventricular (LV) ischemia demonstrate a unique miRNA profile; however, these models have limitations in describing human disease. In this study, we performed next-generation miRNA and mRNA sequencing on LV tissue from nine patients undergoing cardiac surgery with cardiopulmonary bypass and cardioplegic arrest. Samples were obtained immediately after aortic cross clamping (baseline) and before aortic cross ...[more]